{"id":531,"date":"2024-10-13T23:05:47","date_gmt":"2024-10-13T23:05:47","guid":{"rendered":"https:\/\/phongtraoduytan.com\/?p=531"},"modified":"2024-10-13T23:05:47","modified_gmt":"2024-10-13T23:05:47","slug":"giai-nobel-y-hoc-duoc-trao-cho-nghien-cuu-ve-microrna-dieu-hoa-gen","status":"publish","type":"post","link":"https:\/\/diendanduytan.com\/?p=531","title":{"rendered":"Gi\u1ea3i Nobel Y h\u1ecdc \u0111\u01b0\u1ee3c trao cho nghi\u00ean c\u1ee9u v\u1ec1 \u2018microRNA\u2019 \u0111i\u1ec1u h\u00f2a gen"},"content":{"rendered":"\n
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Victor Ambros (b\u00ean tr\u00e1i) v\u00e0 Gary Ruvkun (b\u00ean ph\u1ea3i) \u0111\u00e3 ph\u00e1t hi\u1ec7n ra microRNA, m\u1ed9t lo\u1ea1i ph\u00e2n t\u1eed gi\u00fap \u0111i\u1ec1u ch\u1ec9nh ho\u1ea1t \u0111\u1ed9ng gen trong c\u00e1c t\u1ebf b\u00e0o c\u1ee7a ch\u00fang ta. \u1ea2nh: Steve Jennings\/Getty cho Gi\u1ea3i th\u01b0\u1edfng \u0110\u1ed9t ph\u00e1.<\/figcaption><\/figure>\n\n\n\n

T\u00e1c gi\u1ea3: Ewen Callaway v\u00e0 Katharine Sanderson<\/p>\n\n\n\n

Victor Ambros v\u00e0 Gary Ruvkun \u0111\u00e3 x\u00e1c \u0111\u1ecbnh m\u1ed9t l<\/em>\u1edb<\/em>p ph\u00e2n t<\/em>\u1eed<\/em> nh\u1ecf c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ki\u1ec3m so\u00e1t bi\u1ec3u hi\u1ec7n gen.  <\/em><\/p>\n\n\n\n

Gi\u1ea3i Nobel Sinh l\u00fd h\u1ecdc hay Y h\u1ecdc n\u0103m 2024 \u0111\u00e3 \u0111\u01b0\u1ee3c trao cho hai nh\u00e0 di truy\u1ec1n h\u1ecdc, nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 kh\u00e1m ph\u00e1 ra microRNA \u2013 m\u1ed9t l\u1edbp ph\u00e2n t\u1eed RNA nh\u1ecf gi\u00fap ki\u1ec3m so\u00e1t c\u00e1ch c\u00e1c gen \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n trong c\u00e1c sinh v\u1eadt \u0111a b\u00e0o. <\/p>\n\n\n\n

Victor Ambros, l\u00e0m vi\u1ec7c t\u1ea1i Tr\u01b0\u1eddng Y \u0110\u1ea1i h\u1ecdc Massachusetts \u1edf Worcester, v\u00e0 Gary Ruvkun t\u1ea1i B\u1ec7nh vi\u1ec7n \u0110a khoa Massachusetts (MGH) \u1edf Boston, \u0111\u00e3 c\u00f9ng chia s\u1ebb gi\u1ea3i th\u01b0\u1edfng tr\u1ecb gi\u00e1 11 tri\u1ec7u krona Th\u1ee5y \u0110i\u1ec3n (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 1 tri\u1ec7u USD), do H\u1ed9i \u0111\u1ed3ng Nobel t\u1ea1i Vi\u1ec7n Karolinska \u1edf Stockholm trao t\u1eb7ng.<\/p>\n\n\n\n

MicroRNA th\u1ef1c hi\u1ec7n nhi\u1ec1u nhi\u1ec7m v\u1ee5 trong c\u00e1c sinh v\u1eadt ph\u1ee9c t\u1ea1p, t\u1eeb ph\u00e1t tri\u1ec3n ph\u00f4i thai cho \u0111\u1ebfn sinh l\u00fd t\u1ebf b\u00e0o. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 suy \u0111o\u00e1n r\u1eb1ng ch\u00fang c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn nh\u1eefng b\u01b0\u1edbc nh\u1ea3y ti\u1ebfn h\u00f3a, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1ef1 ph\u00e1t tri\u1ec3n v\u01b0\u1ee3t tr\u1ed9i c\u1ee7a b\u1ed9 n\u00e3o con ng\u01b0\u1eddi, v\u00e0 ch\u00fang c\u0169ng \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 kh\u1edfi ph\u00e1t c\u1ee7a b\u1ec7nh ung th\u01b0 v\u00e0 c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c.<\/p>\n\n\n\n

Ph\u00e1t bi\u1ec3u t\u1ea1i cu\u1ed9c h\u1ecdp b\u00e1o v\u00e0o ng\u00e0y 7 th\u00e1ng 10, Ruvkun cho bi\u1ebft \u00f4ng \u0111ang mong ch\u1edd \u0111\u01b0\u1ee3c nh\u1eadn gi\u1ea3i Nobel t\u1ea1i bu\u1ed5i l\u1ec5 ch\u00ednh th\u1ee9c s\u1ebd di\u1ec5n ra v\u00e0o cu\u1ed1i n\u0103m nay. \u00d4ng \u0111\u00e3 c\u00f3 d\u1ecbp tr\u1ea3i nghi\u1ec7m tr\u01b0\u1edbc kh\u00f4ng kh\u00ed n\u00e1o nhi\u1ec7t c\u1ee7a bu\u1ed5i l\u1ec5 khi tham gia c\u00f9ng nh\u00e0 h\u00f3a sinh Jack Szostak c\u1ee7a B\u1ec7nh vi\u1ec7n \u0110a khoa Massachusetts (MGH), ng\u01b0\u1eddi \u0111\u1ed3ng nh\u1eadn gi\u1ea3i Nobel Y h\u1ecdc n\u0103m 2009, trong chuy\u1ebfn \u0111i t\u1edbi Stockholm. \u201cH\u1ecd r\u1ea5t bi\u1ebft c\u00e1ch ti\u1ec7c t\u00f9ng,\u201d Ruvkun n\u00f3i.<\/p>\n\n\n\n

NGHI\u00caN C<\/strong>\u1ee8<\/strong>U V<\/strong>\u1eda<\/strong>I GIUN TR\u00d2N<\/strong><\/p>\n\n\n\n

Ambros v\u00e0 Ruvkun, khi c\u00f2n l\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u sau ti\u1ebfn s\u0129 trong c\u00f9ng m\u1ed9t nh\u00f3m, \u0111\u00e3 c\u00f4ng b\u1ed1 nh\u1eefng ph\u00e1t hi\u1ec7n quan tr\u1ecdng \u0111\u1ea7u ti\u00ean c\u1ee7a h\u1ecd v\u00e0o n\u0103m 1993. H\u1ecd \u0111\u00e3 x\u00e1c \u0111\u1ecbnh hai gen \u2014 g\u1ecdi l\u00e0 lin-4 v\u00e0 lin-14 \u2014 c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a lo\u00e0i giun tr\u00f2n Caenorhabditis elegans<\/em>. \u0110\u1ed9t bi\u1ebfn trong c\u00e1c gen n\u00e0y ng\u0103n c\u1ea3n ph\u00f4i giun tr\u00f2n ph\u00e1t tri\u1ec3n b\u00ecnh th\u01b0\u1eddng. Ambros ph\u00e1t hi\u1ec7n r\u1eb1ng gen lin-4 b\u1eb1ng c\u00e1ch n\u00e0o \u0111\u00f3 \u0111\u00e3 ch\u1eb7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a gen lin-14, nh\u01b0ng kh\u00f4ng r\u00f5 li\u1ec7u \u0111\u00f3 l\u00e0 t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp hay gi\u00e1n ti\u1ebfp. L\u00e0m vi\u1ec7c t\u1ea1i c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m ri\u00eang bi\u1ec7t, Ambros b\u1eaft \u0111\u1ea7u x\u00e1c \u0111\u1ecbnh b\u1ea3n \u0111\u1ed3 gen ch\u1ecbu tr\u00e1ch nhi\u1ec7m s\u1ea3n xu\u1ea5t lin-4, trong khi Ruvkun ban \u0111\u1ea7u t\u1eadp trung v\u00e0o gen lin-14.<\/p>\n\n\n\n

Khi Ambros x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c gen lin-4, \u00f4ng ng\u1ea1c nhi\u00ean khi ph\u00e1t hi\u1ec7n r\u1eb1ng n\u00f3 kh\u00f4ng m\u00e3 h\u00f3a m\u1ed9t lo\u1ea1i protein, m\u00e0 thay v\u00e0o \u0111\u00f3 l\u1ea1i s\u1ea3n sinh ra m\u1ed9t \u0111o\u1ea1n RNA ng\u1eafn \u0111\u00e1ng ch\u00fa \u00fd. Nghi\u00ean c\u1ee9u c\u1ee7a Ruvkun v\u1ec1 gen lin-14 \u2014 gen m\u00e3 h\u00f3a m\u1ed9t lo\u1ea1i protein \u2014 \u0111\u00e3 gi\u00fap ho\u00e0n thi\u1ec7n b\u1ee9c tranh. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n r\u1eb1ng \u0111o\u1ea1n RNA lin-4, sau n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 microRNA, b\u00e1m v\u00e0o m\u1ed9t \u0111o\u1ea1n RNA th\u00f4ng tin c\u1ee7a lin-14, ng\u0103n c\u1ea3n qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p protein th\u00f4ng qua qu\u00e1 tr\u00ecnh g\u1ecdi l\u00e0 d\u1ecbch m\u00e3.<\/p>\n\n\n\n

Trong nhi\u1ec1u n\u0103m, ph\u00e1t hi\u1ec7n n\u00e0y \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t \u0111\u1eb7c \u0111i\u1ec3m \u0111\u1ed9c nh\u1ea5t c\u1ee7a lo\u00e0i giun tr\u00f2n v\u00e0 kh\u00f4ng c\u00f3 nhi\u1ec1u li\u00ean quan \u0111\u1ebfn c\u00e1c sinh v\u1eadt kh\u00e1c. Quan \u0111i\u1ec3m \u0111\u00f3 \u0111\u00e3 b\u1ecb ph\u00e1 v\u1ee1 v\u00e0o n\u0103m 2000 khi nh\u00f3m c\u1ee7a Ruvkun x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ed9t microRNA kh\u00e1c trong C. elegans<\/em>, kh\u00e1c v\u1edbi lin-4, v\u00e0 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf ng\u01b0\u1eddi, chu\u1ed9t v\u00e0 h\u1ea7u h\u1ebft c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt kh\u00e1c.<\/p>\n\n\n\n

T\u1ea1i cu\u1ed9c h\u1ecdp b\u00e1o, Ruvkun \u0111\u00e3 k\u1ec3 l\u1ea1i kho\u1ea3nh kh\u1eafc \u00f4ng ph\u00e1t hi\u1ec7n ra r\u1eb1ng microRNA kh\u00f4ng ch\u1ec9 gi\u1edbi h\u1ea1n \u1edf giun tr\u00f2n. C\u1ea7n m\u1ed9t ch\u00fat xao nh\u00e3ng trong khi vi\u1ebft \u0111\u01a1n xin t\u00e0i tr\u1ee3 \u1edf nh\u00e0, \u00f4ng \u0111\u00e3 s\u1eed d\u1ee5ng m\u1ed9t modem quay s\u1ed1 ch\u1eadm \u0111\u1ec3 ki\u1ec3m tra xem li\u1ec7u d\u1ef1 th\u1ea3o b\u1ed9 gen ng\u01b0\u1eddi \u2014 v\u1eabn \u0111ang trong qu\u00e1 tr\u00ecnh ho\u00e0n thi\u1ec7n v\u00e0o th\u1eddi \u0111i\u1ec3m \u0111\u00f3 \u2014 c\u00f3 ch\u1ee9a m\u1ed9t microRNA th\u1ee9 hai m\u00e0 ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng \u0111\u00e3 m\u00f4 t\u1ea3 hay kh\u00f4ng. \u201cK\u1ebft qu\u1ea3 tr\u1edf l\u1ea1i tr\u00f9ng kh\u1edbp v\u1edbi b\u1ed9 gen ng\u01b0\u1eddi, t\u00f4i \u0111\u00e3 ngh\u0129 r\u1eb1ng \u2018Ch\u00faa \u01a1i, \u0111i\u1ec1u n\u00e0y th\u1eadt tuy\u1ec7t v\u1eddi,\u2019\u201d \u00f4ng n\u00f3i.<\/p>\n\n\n\n

M\u1eb7c d\u00f9 b\u1ed9 gen ng\u01b0\u1eddi ch\u1ee9a h\u00e0ng tr\u0103m microRNA (kho\u1ea3ng 600 lo\u1ea1i ri\u00eang bi\u1ec7t, nhi\u1ec1u h\u01a1n b\u1ea5t k\u1ef3 sinh v\u1eadt n\u00e0o kh\u00e1c), Ruvkun t\u1eeb l\u00e2u \u0111\u00e3 b\u1ecb thu h\u00fat b\u1edfi s\u1ef1 th\u1eadt r\u1eb1ng con ng\u01b0\u1eddi v\u00e0 c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa kh\u00e1c d\u01b0\u1eddng nh\u01b0 \u0111\u00e3 lo\u1ea1i b\u1ecf nhi\u1ec1u ph\u00e2n t\u1eed RNA nh\u1ecf c\u00f3 m\u1eb7t \u1edf c\u00e1c sinh v\u1eadt nh\u01b0 b\u1ecd c\u1ea1p, ve, s\u00f2 v\u00e0 giun tr\u00f2n C. elegans<\/em> \u2014 ngu\u1ed3n c\u1ea3m h\u1ee9ng trong ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng. Ch\u00fang t\u1ed3n t\u1ea1i trong \u201cnh\u1eefng sinh v\u1eadt ch\u1ea5t nh\u1ea5t tr\u00ean h\u00e0nh tinh \u2014 v\u00e0 \u0111i\u1ec1u \u0111\u00f3 l\u00e0m cho nh\u1eefng con giun nh\u1ecf c\u1ee7a ch\u00fang t\u00f4i c\u0169ng tr\u1edf n\u00ean ch\u1ea5t l\u1eeb,\u2019\u201d \u00f4ng n\u00f3i.<\/p>\n\n\n\n

KHO\u1ea2NH KH\u1eaeC B<\/strong>\u01af\u1eda<\/strong>C NGO\u1eb6T<\/strong><\/p>\n\n\n\n

Vi\u1ec7c ph\u00e1t hi\u1ec7n ra r\u1eb1ng microRNA \u0111\u01b0\u1ee3c b\u1ea3o t\u1ed3n xuy\u00ean su\u1ed1t c\u00e1c lo\u00e0i trong c\u00e2y s\u1ef1 s\u1ed1ng \u0111\u00e3 khi\u1ebfn l\u0129nh v\u1ef1c n\u00e0y b\u00f9ng n\u1ed5. \u201c\u0110\u00f3 l\u00e0 m\u1ed9t kho\u1ea3nh kh\u1eafc mang t\u00ednh b\u01b0\u1edbc ngo\u1eb7t, khi m\u1ecdi ng\u01b0\u1eddi nh\u1eadn ra\u2026 ch\u00fang ta \u0111\u00e3 ho\u00e0n to\u00e0n b\u1ecf l\u1ee1 m\u1ed9t l\u1edbp \u0111i\u1ec1u h\u00f2a gen,\u201d Eric Miska, nh\u00e0 sinh h\u1ecdc RNA t\u1ea1i \u0110\u1ea1i h\u1ecdc Cambridge, V\u01b0\u01a1ng qu\u1ed1c Anh, cho bi\u1ebft. \u201cC\u00e1i s\u00e0ng ch\u00fang ta \u0111\u00e3 d\u00f9ng \u0111\u1ec3 t\u00ecm ki\u1ebfm gen qu\u00e1 l\u1edbn.\u201d<\/p>\n\n\n\n

C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean chu\u1ed9t v\u1edbi c\u00e1c gen m\u00e3 h\u00f3a microRNA b\u1ecb \u0111\u1ed9t bi\u1ebfn cho th\u1ea5y r\u1eb1ng microRNA \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 ph\u00e1t tri\u1ec3n, sinh l\u00fd, h\u00e0nh vi v\u00e0 c\u00e1c t\u00ednh tr\u1ea1ng kh\u00e1c, theo David Bartel, nh\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed t\u1ea1i Vi\u1ec7n Whitehead \u1edf Cambridge, Massachusetts. Tuy nhi\u00ean, vi\u1ec7c x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c c\u00e1ch m\u00e0 c\u00e1c ph\u00e2n t\u1eed ri\u00eang l\u1ebb ho\u1ea1t \u0111\u1ed9ng l\u00e0 m\u1ed9t nhi\u1ec7m v\u1ee5 kh\u00f3 kh\u0103n. M\u1ed9t microRNA v\u00e0 c\u00e1c h\u1ecd h\u00e0ng g\u1ea7n c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 thay \u0111\u1ed5i ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u00e0ng tr\u0103m gen kh\u00e1c nhau, v\u00e0 nhi\u1ec1u gen l\u1ea1i \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi h\u01a1n m\u1ed9t microRNA. \u201cM\u1ecdi th\u1ee9 tr\u1edf n\u00ean ph\u1ee9c t\u1ea1p r\u1ea5t nhanh,\u201d Bartel cho bi\u1ebft.<\/p>\n\n\n\n

L\u0129nh v\u1ef1c tr\u1ecb li\u1ec7u b\u1eb1ng microRNA v\u1eabn c\u00f2n \u1edf giai \u0111o\u1ea1n s\u01a1 khai, nh\u01b0ng c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hy v\u1ecdng r\u1eb1ng m\u1ed9t ng\u00e0y n\u00e0o \u0111\u00f3 c\u00f3 th\u1ec3 t\u1eadn d\u1ee5ng c\u00e1c ch\u1ea5t \u0111i\u1ec1u h\u00f2a ch\u00ednh n\u00e0y \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh. Hi\u1ec7n c\u00f3 m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c microRNA \u0111ang \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n, nh\u01b0ng vi\u1ec7c \u0111\u01b0a c\u00e1c ph\u00e2n t\u1eed RNA v\u00e0o trong t\u1ebf b\u00e0o l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn, Miska n\u00f3i.<\/p>\n\n\n\n

Vi\u1ec7c c\u00f4ng nh\u1eadn microRNA b\u1eb1ng gi\u1ea3i Nobel l\u00e0 m\u1ed9t b\u1ea5t ng\u1edd th\u00fa v\u1ecb \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 nh\u00e0 nghi\u00ean c\u1ee9u. N\u0103m 2006, \u1ee6y ban Nobel \u0111\u00e3 trao gi\u1ea3i th\u01b0\u1edfng y h\u1ecdc hay sinh l\u00fd h\u1ecdc cho hai nh\u00e0 nghi\u00ean c\u1ee9u v\u00ec ph\u00e1t hi\u1ec7n c\u1ee7a h\u1ecd v\u1ec1 m\u1ed9t c\u01a1 ch\u1ebf t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 can thi\u1ec7p RNA, m\u1ed9t c\u01a1 ch\u1ebf m\u00e0 microRNA v\u00e0 c\u00e1c ph\u00e2n t\u1eed RNA kh\u00f4ng m\u00e3 h\u00f3a kh\u00e1c s\u1eed d\u1ee5ng \u0111\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng c\u1ee7a gen. <\/p>\n\n\n\n

\u201cC\u00e1c gen microRNA gi\u1edd \u0111\u00e2y \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t l\u1edbp \u0111i\u1ec1u h\u00f2a gen ho\u00e0n to\u00e0n m\u1edbi trong b\u1ed9 gen c\u1ee7a ch\u00fang ta,\u201d Gunter Meister, nh\u00e0 h\u00f3a sinh t\u1ea1i \u0110\u1ea1i h\u1ecdc Regensburg, \u0110\u1ee9c, cho bi\u1ebft.<\/p>\n\n\n\n

\u201c\u0110\u00e2y l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf sinh l\u00fd ho\u00e0n to\u00e0n m\u1edbi m\u00e0 kh\u00f4ng ai ng\u1edd t\u1edbi,\u201d th\u00e0nh vi\u00ean \u1ee7y ban Olle K\u00e4mpe, m\u1ed9t nh\u00e0 n\u1ed9i ti\u1ebft h\u1ecdc t\u1ea1i Karolinska, cho bi\u1ebft trong bu\u1ed5i c\u00f4ng b\u1ed1 gi\u1ea3i th\u01b0\u1edfng. C\u00f4ng tr\u00ecnh n\u00e0y l\u00e0m n\u1ed5i b\u1eadt t\u1ea7m quan tr\u1ecdng c\u1ee7a s\u1ef1 t\u00f2 m\u00f2 trong nghi\u00ean c\u1ee9u, \u00f4ng n\u00f3i th\u00eam. \u201cH\u1ecd nh\u00ecn v\u00e0o hai con giun tr\u00f4ng c\u00f3 v\u1ebb h\u01a1i bu\u1ed3n c\u01b0\u1eddi v\u00e0 quy\u1ebft \u0111\u1ecbnh t\u00ecm hi\u1ec3u t\u1ea1i sao. V\u00e0 sau \u0111\u00f3, h\u1ecd ph\u00e1t hi\u1ec7n ra m\u1ed9t c\u01a1 ch\u1ebf ho\u00e0n to\u00e0n m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u h\u00f2a gen. T\u00f4i ngh\u0129 \u0111i\u1ec1u \u0111\u00f3 th\u1eadt tuy\u1ec7t v\u1eddi.\u201d<\/p>\n\n\n\n

Ngu\u1ed3n: Ewen Callaway v\u00e0 Katharine Sanderson, “Medicine Nobel awarded for gene-regulating \u2018microRNAs<\/a>\u2019\u201d, Nature<\/em>, 7\/10\/2024<\/p>\n\n\n\n

Bi\u00ean d\u1ecbch: Phong tr\u00e0o Duy T\u00e2n<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Victor Ambros v\u00e0 Gary Ruvkun \u0111\u00e3 x\u00e1c \u0111\u1ecbnh m\u1ed9t l\u1edbp ph\u00e2n t\u1eed nh\u1ecf c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ki\u1ec3m so\u00e1t bi\u1ec3u hi\u1ec7n gen.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[68,91,122],"class_list":["post-531","post","type-post","status-publish","format-standard","hentry","category-cong-nghe","tag-ewen-callaway","tag-katharine-sanderson","tag-nobel-2024"],"_links":{"self":[{"href":"https:\/\/diendanduytan.com\/index.php?rest_route=\/wp\/v2\/posts\/531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diendanduytan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diendanduytan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diendanduytan.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/diendanduytan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=531"}],"version-history":[{"count":0,"href":"https:\/\/diendanduytan.com\/index.php?rest_route=\/wp\/v2\/posts\/531\/revisions"}],"wp:attachment":[{"href":"https:\/\/diendanduytan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diendanduytan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diendanduytan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}